APC anti-mouse/human SEMA4A

Antibodies Single
Sony
5E3/SEMA4A
Flow Cytometry
Mouse IgG1, λ
Human,Mouse
Mouse SEMA4A-Fc proteins
1342030
$290.00

Description

Semaphorin 4A (SEMA4A) is a class IV semaphorin of soluble and transmembrane proteins originally identified as SemB. It is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain, and a Sema domain. SEMA4A is expressed on dendritic cells, activated B cells, and T cells. It is also found on different tissues, such as those in brain, lung, kindney, spleen, and testis. In the immune system, SEMA4A functions as an activator in the T-cell-mediated immune response and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Like other semaphorin family members it is also involved in guidance of axonal migration during neuronal development and in immune responses.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.125 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

References

1. Kumanogoh A, et al. 2002. Nature. 419:629. 
2. Kumanogoh A, et al. 2005. Immunity. 22:305. 
3. Toyofuku T, et al. 2007. EMBO J. 26:1373. 
4. Delgoffe GM, et al.<