Alexa Fluor® 488 anti-mouse CD16.2 (FcγRIV)

Antibodies Single
Sony
9E9
Flow Cytometry
Hamster IgG
Mouse
FCγR4 –EC domain fusion with IgG1 Fc
1347615
$121.00

Description

FcγRIV, also known as CD16.2, is an intermediate-affinity activating receptor for IgG2a and IgG2b. CD16.2 is the mouse homolog of human FcγRIIIA. CD16.2 is a low-affinity IgE receptor for all allotypes and the ligation of FcγRIV by antigen-IgE immune complexes promotes macrophage-mediated phagocytosis and is involved in lung inflammation.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 microg per million cells in 100 microL volume. It is recommended that the reagent be titrated for optimal performance for each application.

* Alexa Fluor® 488 has a maximum emission of 519 nm when it is excited at 488 nm.

References

1. Mancardi DA, et al. 2008. J. Clin. Invest 118:3738. (FC, Block)
2. Nimmerjahn F, et al. 2005. Immunity 23:41.