Description

The invariant TCR zeta chain is a member of the CD3 complex associated with the clonotypic α/β TCR heterodimer. The disulfide-linked TCR zeta homodimers transmit signals following TCR ligation. Loss of TCR zeta expression has been reported in a diverse range of disease states, including autoimmune diseases, many neoplastic conditions and chronic infections, such as tuberculosis and leprosy.

Formulation

Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.2 microg per million cells in 100 microL volume. It is recommended that the reagent be titrated for optimal performance for each application.

References

1.Zhang Z, et al. 2007. Blood 109:4328. (Block)
2.Gorman CL, et al. 2008. J. Immunol. 180:1060.
3.Jenson WA, et al. 1997. Eur J. Immunol. 27:707.
4. Mao H, et al. 2010. J. Virol. 84:4148. PubMed
5. Hwang I, et al. 2012. Int Immunol. 24:793. PubMed.