APC anti-human CD158 (KIR2DL1/S1/S3/S5)

Antibodies Single
Sony
HP-MA4
Flow Cytometry
Mouse IgG2b, κ
Human
Human NK cell clone LB2
2297550
$318.00

Description

CD158 molecules, also known as KIRs (killer cell immunoglobulin-like receptors), are a family of transmembrane proteins with either two (KIR2D) or three (KIR3D) Ig-like extracellular domains. Some KIRs with long cytoplasmic domains contain ITIMs and posses inhibitory functions and others with short cytoplasmic region lack ITIM and have activation functions. 14 polymorphic KIR genes have been reported in humans. CD158 is mainly expressed on a subset of NK cells and a small population of CD8+ T cells. HLA-C is the ligand of CD158a/h.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 microL per million cells or 5 microL per 100 microL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

References

1. De Miguel M and M. Lopez-Botet. 2002. Inmunologia. 21:187
2. Goodridge JP, et al. 2013. J. Immunol. 191:3553. PubMed