APC anti-human CD163

Antibodies Single
Sony
RM3/1
Flow Cytometry
Mouse IgG1, κ
Human
Human monocytes
2232545
$128.00

Description

CD163 is a member of the group B scavenger receptor cysteine-rich superfamily, also known as GHI/61, M130, RM3/1, p155, hemoglobin-haptoglobin complex receptor, or macrophage-associated antigen. It is a 134 kD (non-reduced)/155 kD (reduced) glycoprotein primarily expressed on macrophages, Kuffer cells, monocytes, subset of dendritic cells, and a subset of hematopoietic stem/progenitor cells. CD163 binds to haptoglobin-hemoglobin complex and TWEAK, and plays a role in clearing hemoglobin and regulating cytokine production by macrophages. Membrane CD163 can be cleaved by metalloproteinases (MMP), resulting in a soluble form. Elevated serum level of sCD163 has been implicated in many kinds of inflammation diseases.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 microL per million cells or 5 microL per 100 microL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

References

1. Högger P, et al. 1998. J. Immunol. 161:1883. (FC)
2. Zwadlo G, et al. 1987. Exp. Cell Biol. 55:295. (FC)
3. Buechler C, et al. 2000. J. Leukoc. Biol. 67:97. (FC)
4. Puig-Kroger A, et al. 2009. Cancer Res. 69:9395. (FC) PubMed
5. Madsen M, et al. 2004. J. Biol. Chem. 279:51561. (FC)
6. Jones K, et al. 2013. Clin Cancer Res. 19:731. (FC) PubMed
7. Stewart DA, et al. 2012. Mol. Cancer Res. 10:727. (IF)