Alexa Fluor® 647 anti-human CD137 (4-1BB)
Description
CDw137 is a 39 kD transmembrane protein also known as 4-1BB. It is expressed on activated T cells. CDw137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily. CDw137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 microL per million cells or 5 microL per 100 microL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.
References
1. Garni-Wagner B, et al. 1996. Cell. Immunol. 169:91. (IP)
2. Salih HR, et al. 2000. J. Immunol. 165:2903. (FA)
3. Kienzle G, et al. 2000. Int. Immunol. 12:73. (FA)
4. Langstein J, et al. 1998. J. Immunol. 160:2488. (IP)