PE/Cy7 anti-mouse Tim-4

Antibodies Single
Sony
RMT4-54
Flow Cytometry
Rat IgG2a, κ
Mouse
Mouse TIM4-Ig fusion protein
1250045
$145.00

Description

Tim-4 is a transmembrane protein known as T cell immunoglobulin and mucin domain containing protein-4. It is expressed on antigen-presenting cells and not on T cells. Tim-4 binds to Tim-1 to promote T cell proliferation by enhancing cell division and reducing apoptosis. Tim-4 bind to phosphatidylserine through its FG-CC’ binding cleft in the N-terminal IgV domain to facilitate the clearance of apoptotic cells or bodies.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 microg per million cells in 100 microL volume. It is recommended that the reagent be titrated for optimal performance for each application.

References

1. Nakayama M, et al. 2009. Blood. 113:3821. (FA)
2. Yeung MY, et al. 2013. J. Immunol. 191:4447. (Block)