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- Sony Biotechnology
- Sony Biotechnology
CD28 is a 44 kD glycoprotein, also known as Tp44 or T44. It is a member of the Ig superfamily, expressed on thymocytes, most peripheral T cells, and NK cells. In association with CD80 (B7-1) and CD86 (B7-2), CD28 acts as the second signal for T and NK cell activation and proliferation. The 37.51 antibody has been reported to augment in vitro T cell proliferation and cytokine production, and promote CTL development.
1. Gross JA, et al. 1992. J. Immunol. 149:380. (IP, Costim)
2. Cibotti R, et al. 1997. Immunity 6:245. (Costim)
3. Masten BJ, et al. 1997. Am. J. Respir. Cell Mol. Biol. 16:335. (Block)
4. Nishio M, et al. 1996. J. Immunol. 157:4347. (Block)
5. Zhang N and He Y-W, 2005. J. Exp. Med. 202:395. (Costim)
6. Terrazas LI, et al. 2005. Intl. J. Parasitology. 35:1349. (Costim)
7. Perchonock CE, et al. 2006. Mol Cell Biol. 26(16):6005. (Costim)
8. Wang W, et al. 2007. J. Immunol. 178:4885. (Costim)
9. Pua HH, et al. 2007. J. Exp. Med. 204:25. (Costim)
10. Perchonock CE, et al. 2007. J. Immunol. 179:1768.
11. Barbi J, et al. 2007. Blood 110:2215.
12. Milpied P, et al. 2011. Blood 118:2993. PubMed
13. Cunningham NR, et al. 2011. Int Immunol. 23:693. PubMed