PerCP/Cy5.5 anti-mouse/rat CD42d

Antibodies Single
Sony
1C2
Flow Cytometry
Hamster IgG
Mouse,Rat
Mouse platelets
1342540
$341.00

Description

CD42d is an 83 kD surface glycoprotein that non-covalently associates with GPIb and GPIX to form a receptor complex for von Willebrand factor on megakaryocytes and resting platelets. Binding sites for von Willebrand factor and thrombin have been localized to the GPIba chain of the GPI-b-V-IX complex. Platelet activation with thrombin cleaves the GPI-b-V-IX complex to release a 69 kD soluble fragment. Presence of the GPI-b-V-IX complex is important in Bernard-Soulier syndrome, a rare bleeding disorder.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 microg per million cells in 100 microL volume. It is recommended that the reagent be titrated for optimal performance for each application.

* PerCP/Cy5.5 has a maximum absorption of 482 nm and a maximum emission of 690 nm.

References

1. Takada K, et al. 1995. Hybridoma. 14:361. (IP)
2. Saito M, et al. 1996. Stem Cells. 14:124. (FC)
3. Sato N, et al. 2000. Hybridoma. 19:455. (IP)