Biotin anti-mouse CD51

Antibodies Single
Sony
RMV-7
Flow Cytometry
Rat IgG1, κ
Mouse
BALB/c mouse IL-2-activated killer (LAK) cells
1120520
$260.00

Description

CD51 is a 140 kD protein, also known as αV integrin, vitronectin receptor, and integrin αV. It is a member of the integrin family, expressed on activated T cells, polymorphonuclear granulocytes, platelets, blastocysts, and osteoclasts. CD51 forms heterodimers by association with integrins β1, β3, β5 or β6; these complexes then act as receptors for multiple extracellular matrix proteins (ECM). The αv integrin heterodimers have varied functions in development, stimulation/activation and homeostasis. The primary ligands for CD51 complexes are fibronectin, fibrinogen, vitronectin, thrombspondin, von Willebrand factor, and CD31. The RMV-7 antibody has been reported to block binding of CD51 to vitronectin, fibronectin, and CD31 in some cell types, as well as blocking LAK cell cytotoxicity.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 microg per 106 cells in 100 microL volume. It is recommended that the reagent be titrated for optimal performance for each application.

References

1. Takahashi K, et al. 1990. J. Immunol. 145:4371. (IP Block)
2. Narumiya S, et al. 1994. Int. Immunol. 6:139. (Block)
3. Piali L, et al. 1995. J. Cell Biol. 130:451. (Block)
4. Delpino MV, et al. 2012. J. Leukoc Biol 91:285. PubMed.