About Sony Biotechnology

  • Sorting a 12-Color Immunophenotyping Panel with the MA900 Cell Sorter

    16 Sep 2019

    See the results of sorting a 12-color immunophenotyping panel for T-cell, B-cell, NK-cell, and monocyte subsets using the MA900 cell sorter. Learn more about how 4 lasers, 12 fluorescence parameters, and 4-way sorting can dramatically simplify operation to make sorting less subjective and improve reliability.

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  • Barcoding Nuclei to Illuminate Single-Cell Epigenetics

    30 Aug 2019

    Single-cell sequencing has proven invaluable to understanding the biology of heterogeneous samples such as brain or tumor tissues. However, sorting individual cells into wells for downstream sequencing does not provide adequate throughput needed for meaningful analysis of the epigenetic states of the cells. To address this challenge, this research team developed a new methodology to analyze properties of single cells by labeling cell nuclei with DNA "barcodes" and distributing them using the SH800 sorter from Sony Biotechnology.

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  • Pandemic Prevention: The Sprint Toward Protective Antibody Treatments

    01 Jul 2019

    Can antibodies be used as potential complements to vaccines? This team scours the planet looking for human donors to isolate PBMCs from those exposed to Rift Valley Fever in Kenya, to Ebola survivors. Supporting this important work, the Sony SH800 cell sorter has become an essential tool to isolate the right cells for a pipeline to generate antibody sequences that will ultimately build effective medical countermeasures.

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  • Regenerating Visual Pathways with CRISPR Modified Stem Cells

    29 May 2019

    Learn how scientists have built a scalable approach using CRISPR-Cas9 and the SH800 cell sorter from Sony to research restoring vision in people with optic neuropathies.

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  • Easy-To-Use, Automated Cleaning on the MA900 for Sorting in Multi-User Labs

    20 May 2019

    Learn how the automated cleaning function of the MA900 Multi-Application Cell Sorter saves time and reduces errors for multi-user labs.

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  • Engineering New Functionality into Cas9

    01 May 2019

    David Savage's laboratory uses progressive cell sorting of large libraries to allosterically engineer protein biosensors and direct the genome editing activity of Cas9. Second in a series of real-world applications for the Sony SH800 cell sorter.

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  • Induced Pluripotent Stem Cells Show Potential for Autologous Stem Cell Therapies

    22 Apr 2019

    A study of porcine iPS cells in an SLA-matched setting is a possible robust model for transplantation of human iPS cells in an HLA-matched setting. The Sony SH800 was used to perform the NK mediated cytotoxicity assay.

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  • Modeling Cardiac Abnormalities in Stem Cell-Derived Cardiomyocytes

    07 Feb 2019

    Learn how a developmental cell biology lab combined single-cell sorting with RNA sequencing to accelerate stem cell maturation and model cardiac abnormalities. This is the first in our profile series of real-world applications for the Sony SH800 cell sorter.

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  • Similar but not the same - Genome sequencing of sorted single cells

    09 Nov 2017

    Learn how the Sony SH800S cell sorter supports gene expression profiling to purify phenotypically similar cell populations in bulk.

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  • Detection of in vivo cell movement by flow cytometry

    16 Oct 2017

    Researchers used spectral flow cytometry and fluorescent proteins to capture both movement and interactions of immune cells in live mice.

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