About Sony Biotechnology

  • Standardization In - Variability Out – Reliable Data from your Cell Analyzer

    25 May 2017

    As most researchers know, all instruments have some variability and over time settings continue to drift. Obviously, instrument variability is “bad” because it can unwittingly impact your data – forcing you to re-run experiments to determine what caused data anomalies.

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  • Using cell sorting to isolate cells with genes edited by CRISPR-Cas9

    19 May 2017

    With the ability to easily identify and isolate single cells from a heterogeneous phenotypic population, a cell sorter is a useful tool for laboratories studying and applying the CRISPR technology as a tool for editing genes and creating single cell libraries.

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  • How the immune system impacts liver regeneration

    18 May 2017

    Unlike most organs in the human body the liver is able to regenerate allowing donors and patients to re-grow resected tissue. The success and rate of regeneration can be negatively impacted by several factors including sub-septic conditions. One factor is LFA-1, an integrin lymphocyte function-associated antigen-1.

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  • Simple Panels for the Study of T-Cells

    01 May 2017

    T-cells are part of the adaptive immune system with several subtypes including CD8+ effector T-cells and CD4+ helper T-cells. Main categories can be divided into several sub-categories. What are the critical markers to study T-cells? From the key subsets how can other subsets be defined?

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  • Explain CRISPR-Cas-9 to your Mom

    01 May 2017

    Thank your super hero mom this Mother’s Day by giving her some quality time and something to remember—the gift of knowing about the work you do that makes the world a better place. To help you with what could be the best little talk ever here’s a 5-minute animation from the Royal Society that explains gene editing and the importance CRISPR-Cas-9 we hope you will find useful. Happy Mother’s Day to all, thank you for what you do. Video: What is gene editing and how does it work?

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  • Selecting the Best Clone for Your Flow Cytometry Experiments

    03 Apr 2017

    With literally thousands of commercially available fluorochrome conjugated antibodies for flow cytometry, there are many choices for your application. In many cases several clones are available to the same target. How do you evaluate which clones are best for your research?

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  • Make the Connection: Cell Sorting to Separate Brain Cells

    03 Apr 2017

    Cell sorting is a valuable technique for isolating cells from mixed populations. This technique can be challenging when working with tissues such as brain, as it requires single cell suspensions. With recent advances in genome editing and fluorescent protein applications, the interest in sorting brain cells has been increasing. Several studies have been published in which scientists have successfully isolated stem cells from whole brain homogenate using cell sorting.
    Guidelines for sorting brain cells.

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  • Cystic Fibrosis Foundation Therapeutics in Boston BizJournal

    19 Apr 2016

    To identify and test new treatments for cystic fibrosis, Cystic Fibrosis Foundation Therapeutics Inc. has opened a new laboratory in Lexington, MA. The team of 25 will focus on the discovery of promising drugs for both common and rare mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. For cell sorting the lab selected the Sony SH800 (placed inside a biosafety cabinet).

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