Description

CD200R, also known as OX2R, is a membrane glycoprotein with up to 70% of its weight derived from N-linked glycosylation. CD200R is expressed primarily by monocytes and neutrophils but also by other leukocytes including T lymphocytes and mast cells. The interaction between CD200 and CD200R may contribute to pathways that suppress and limit macrophage induced inflammatory damage in tissue. Studies suggest that CD200-CD200R interaction may be involved in the control of myeloid cellular function. Levels of expression on resting peripheral blood cells are relatively low.

Formulation

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

References

1. Voulgaraki D, et al. 2005. Immunol. 115:337
2. Stumper TL, et al. 2011. J. Immunol. 186:1970. PubMed
3. Talebian F, et al. 2012. PLoS One 7:e31442. (FA)