How the immune system impacts liver regeneration

Unlike most organs in the human body the liver is able to regenerate allowing donors and patients to re-grow resected tissue. The success and rate of regeneration can be negatively impacted by several factors including sub-septic conditions. One factor is LFA-1, an integrin lymphocyte function-associated antigen-1.

To better understand how LFA-1 affect liver regeneration, Jörger, et al. used a mouse model to determine the functional role of immune cells, especially NKT cells, in response to partial hepatectomy. In this study lymphocytes were characterized on the Sony SP6800 spectral analyzer to determine innate and adaptive immune cells in liver regeneration. In addition, the study determined that NKT lymphocytes were examined to determine their ability to play a protective role in liver regeneration.

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References

Jörger AK, et al. "Impact of NKT Cells and LFA-1 on Liver Regeneration under Subseptic Conditions." PLoS One 2016 11(12): e0168001. PubMed